李慧颖|教授
教育背景
2005.07 山东大学生命科学院 理学学士（生物学）
2011.07 清华大学生命科学院 理学博士（生物学）
工作经历
2011.10-2015.07 清华大学生物信息学国家重点实验室 博士后、助研
2016.07-2022.07 中国农业科学院 助研、副研究员（研究生导师）
2022.07 至今 北京林业大学太阳贵宾会 副教授、教授（研究生导师）
研究方向
食药同源天然活性成分功能评价及相关机制研究；药品和保健食品研发等
联系方式：lihuiying1983@bjfu.edu.cn
部分个人科研成果（文章、专利、编写著作等）
近年来，在药食同源研究领域，发表SCI论文和中文期刊论文60余篇，其中以第一作者或通讯作者50余篇。总IF约260，总被引1400余次。部分代表性论文如下：
1 Microplastics from polystyrene and polyethylene posed reproductive toxicity on male mice through regulating RXFP2 m6A/mTOR/PI3K/NF-κB axis. Food Science and Human Wellness (be accepted), 2026.
2 Quantitative analysis, anti-diabetes bioactivities evaluation and mechanism investigation of acorn polysaccharides from three different species. Food Science and Human Wellness, 2025.
3 Synergistic Effect Evaluation and Mechanism Investigation of Vitamin B6 and B12 in Models of Neuroinflammation. International Journal of Molecular Sciences, 2025.
4 7,8-dihydroxyflavone alleviates ulcerative colitis by inhibiting ferroptosis. Food Science and Human Wellness, 2025.
5 Bamboo leaf flavonoids (BLFs) Suppress the Progression of Alzheimer’s Disease Induced by Circadian Rhythm Disruption Through Regulating Hif3α/Rab7/TNFα/IL1β Pathway. International Journal of Molecular Sciences, 2025.
6 Extraction condition optimization, quantitative analysis and anti-AD bioactivities evaluation of acorn polyphenols in three different species. International Journal of Molecular Sciences, 2024.
7 Evaluation of the Protective Bioactivity and Molecular Mechanism Verification of Lactoferrin in an Alzheimer's Mouse Model with Ulcerative Enteritis. Journal of Dairy Science, 2024.
8 The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model. CNS Neuroscience & Therapeutics, 2024.
9 Circadian rhythm disruption leads to the progression of Alzheimer's disease through regulating m6A methylation of key gene Hif3α. Biology, 2024.
10 Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments. Chinese Medicine, 2023.
11 Anthracycline Chemicals with an-Thracyclinone Structure Exert Antitumor Effects by Inhibiting Angiogenesis and Lymphangiogenesis in A Xenografted Gastric Tumor Model. Gastric Cancer, 2023.
12 Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP /m6A /NT5DC3/HKDC1 axis. Journal of Translational Medicine, 2023.
13 Milk Active Ingredients, 2’-fucosyllactose Inhibits Inflammation and Promotes MUC2 Secretion in
LS174T Goblet Cells in vitro. Foods, 2022.
14 Lactoferrin inhibits the development of T2D to colon tumors by regulating NT5DC3/PI3K/AKT/mTOR signaling pathway. Foods, 2022.
15 Dynamic Regulation of eEF1A1 Acetylation Affects Colorectal Carcinogenesis. Biological Chemistry,
2022.
16 Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer. Frontiers in Immunology, 2022.
17 Lactoferrin Alleviates Lipopolysaccharide-induced Infantile Intestinal Immune Barrier Damage By
Regulating ELAVL1-related Signaling Pathway. International Journal of Molecular Sciences, 2022.
18 2’-Fucosyllactose Suppresses Angiogenesis and Alleviates Toxic Effects of 5-Fu in a HCT116 Colon
Tumor-Bearing Model. Molecules, 2022.
19 2'-fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression. Frontiers in Nutrition, 2022.
20 Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice. Journal of Dairy Science, 2022.
21 Baicalin suppresses the progression of Type II diabetes-induced liver tumor through regulating METTL3/m6A/HKDC1 axis and downstream p-JAK2/STAT1/clevaged Caspase3 pathway. PHYTOmedicine, 2021.
22 Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway. International Immunopharmacology, 2021.
23 The crosstalking between gut microbiome and immune response regulated by diet nutrients in inflammatory bowel disease. Foods, 2021.
24 Lactoferrin could alleviate liver injury caused by Maillard reaction products with furan ring through regulating necroptosis pathway. Food Science & Nutrition, 2021.
25 The combination of lactoferrin and linolenic acid inhibits colorectal tumor growth through activating AMPK/JNK-related apoptosis pathway. Peer J, 2021.
26 Inhibitory effect of lactoferrin on pulmonary inflammatory process induced by lipopolysaccharide through modulating TLR4-related pathway. Journal of Dairy Science, 2021.
27 Angustoline Inhibited Esophageal Tumors Through Regulating LKB1/AMPK/ELAVL1/LPACT2 Pathway And Phospholipid Remodeling. Frontiers in Oncology, 2020.
28 Maillard reaction products with furan ring, like furosine, cause kidney injury through triggering ferroptosis pathway. Food Chemistry, 2020.
29 Investigation and comparison of the protective activities of three functional proteins-lactoferrin, α-lactalbumin, and β-lactoglobulin in cerebral ischemia reperfusion injury. Journal of Dairy Science, 2020.
30 The combination of two bioactive constituents, lactoferrin and linolenic acid, inhibits mouse xenograft esophageal tumor growth by downregulating lithocholyltaurine and inhibiting the JAK2/STAT3-related pathway. ACS Omega, 2020.
31 Toxic effects of furosine by oral intake on liver and kidney and toxicokinetics research in mice acute toxicity model. Food Science and Technology Science, 2020.
32 Modulation activity of heat-treated and untreated lactoferrin on the TLR-4 pathway in anoxia cell model and cerebral ischemia reperfusion mouse model. Journal of Dairy Science, 2019.
33 Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway. International Journal of Molecular Sciences, 2019.
34 Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin and β-lactoglobulin, in A549/HT29/HepG2/MDA231-LM2 tumor models. Journal of Dairy Science, 2019.
35 L-proline alleviates kidney injury caused by AFB1 and AFM1 through regulating excessive apoptosis of kidney cells. Toxins, 2019.
36 Lactoferrin induces the synthesis of vitamin B6 and protects HUVEC functions by activating PDXP and the PI3K/AKT/ERK1/2 pathway. International Journal of Molecular Sciences, 2019.
37 Furosine Posed Toxic Effects on Primary Sertoli Cells through Regulating Cep55/NF-kappa B/PI3K/Akt/FOX01/TNF-alpha Pathway. International Journal of Molecular Sciences, 2019.
38 Effect of heat treatment on the anti-tumor activity of lactoferrin in human colon tumor (HT29) model. Journal of Agricultural and Food Chemistry, 2019. (封面文章)
39 Toxicology studies of furosine in vitro/in vivo and exploration of the related mechanism. Toxicology Letters, 2018, 291:101-111.
40 The toxic effects of aflatoxin B1 and aflatoxin M1 on kidney through regulating L-proline and downstream apoptosis. Biomed Research International, 2018.
41 Furosine induced apoptosis by the regulation of STAT1/STAT2 and UBA7/UBE2L6 genes in HepG2 cells. International Journal of Molecular Sciences, 2018.
42 Lactoferrin exerts anti-tumor effects by inhibiting angiogenesis in a HT29 human colon tumor model. Journal of Agricultural and Food Chemistry, 2017.
43 Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer. Scientific Reports. 2014.
44 A network pharmacology approach to determine active compounds action mechanisms of ge-gen-qin-lian decoction or treatment of Type 2 Diabetes. Evidence-based Complementary and Alternative Medicine. 2014.
45 A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study. Molecular BioSystems. 2014.（封面文章，英国皇家化学会“Top1% 高被引”）
46 Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury. Chinese Medical Journal. 2012.（中国精品科技期刊顶尖学术论文“F5000”）
47 Comparative Study of the Effect of Baicalin and Its Natural Analogs on Neurons with Oxygen and Glucose Deprivation Involving Innate Immune Reaction of TLR2/TNFα. Journal of Biomedicine and Biotechnology. 2012.
48 Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. European Journal of Pharmacology. 2010.
49 基于学科前沿的“食品营养学”“概念+实践式”教学改革探索. 食品工业. 2025.
50 生物信息学课程多层次教学探索概论. 北京林业大学教育教学改革与研究优秀论文汇编. 2022.
申请国家发明专利（排名前三）：
1 一种用于抑制阿尔兹海默症的红花籽油及其制备方法，第一发明人，实审
2 临床肝移植和急性胰腺炎病人全营养代餐粉成分组合，第一发明人，实审
3 一种高程度保留预制菜品营养成分的加工工艺及感官评价方法，第一发明人，实审
4 一种液氮冻存肿瘤组织构建 PDX 模型的构建方法及其试剂组合，第一发明人（202310403824.2），已授权
5 一种改良的PDX模型构建方法及其试剂组合，第一发明人（202211194330.X），已授权
6 一种高通量检测人NT5DC3 蛋白的高灵敏 ELISA 试剂盒, 第一发明人（202211222672.8），实审
7 一种抗癌症的药物组合物，第一发明人（202010176118.5），已授权
8 一种包含乳蛋白和油酸的药物组合物，第一发明人（201911193771.6），已授权
9 一种抗癌症的药物组合物，第二发明人（201911193760.8），已授权
10 一种糠氨酸及其盐的制备方法与流程，第二发明人（201710552985.2），已授权
11 一种含活性蛋白和活性脂肪酸的抗癌症的药物组合物, 第三发明人（202010858954.1），已授权
12 一种天然化合物作为抗糖尿病药物的应用，第三发明人（104644628B），已授权
13 一种生物碱作为阻断肠道炎癌转化和预防肿瘤药物的用途，第二发明人（104510733A），已授权
在北林主持的政府科技攻关、企业科技服务和成果转化类项目（总经费417万元）：
1 重组胶原蛋白润眼液、人工骨修复材料、重组胶原蛋白人工骨粉的功效验证；
2 一种高通量检测人NT5DC3蛋白的高灵敏ELISA试剂盒生产技术（专利权转让）；
3 文冠果功能食品开发及其产业化，北京林业大学中央高校基本科研业务费项目（科技成果转化项目）；
4 脂肪微片段表征分析与鉴定；
5 新型生态肥料功能评价及应用开发；
6 红花籽油营养功能评价及应用开发；
7 不同膳⻝模式下真菌毒素暴露毒性与益⽣菌⼲预机制研究；
8 益生菌缓解真菌毒素和酒精联合暴露引发生殖毒性的分子机制验证；
9 青城奶站0号店项目鲜奶科学研究服务合同书；
10 莲参三仁饮祛湿功效验证；
11 灵芝双参饮提高免疫力功效验证。
12 海南芒果仁油高值利用关键技术研究与产品开发。
13 黄芩苷调节METTL3/m6A/HKDC1信号通路抑制2型糖尿病至肝癌进展的机制研究（北京林业大学科技创新计划项目）。
另外，在2016-2021年间，主持国家农产品质量安全风险评估重大专项课题3项、农业农村部农业标准项目1项、农业农村部重点实验室科技创新课题1项，经费为375万元。
主讲课程：
食品营养学（本科专业必修）；食品安全学（本科专业必修）；认知实习（本科专业必修）；营养与健康（全校公选）；毕业实习（本科专业必修）；食品营养与健康导论（研究生专业选修），等。
学术兼职：
《Food Science and Human Wellness》、《Chinese Medicine》 青年编委
《Frontiers in Immunology》 客座主编
山东明仁福瑞达制药股份有限公司 特聘专家
中研子创（北京）生物科技有限公司 首席专家
人才称号及部分省部级奖项：
1 国家林草科技创新青年拔尖人才（2024年）
2 神农中华农业科技奖一等奖（2018-2019年）
3 神农中华农业科技奖团队奖（2018-2019年）
4 长城食品安全科学技术奖特等奖（2017-2018年）